Cardiothoracic & vascular anaesthesia
Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial
Primary result · Chest drain bleedingResult — go to the resultRatio of geometric means 1.13 95% CI 0.96–1.34Authors' conclusion
Cryopreserved platelets did not meet the predefined threshold for noninferiority in hemostatic effectiveness at 24 hours after ICU admission.
Study context
- Population
- Cardiac surgery patients at high risk of platelet transfusion, 11 Australian tertiary hospitals, 2021–2024202 transfused
- Participants
- 388 patients
- Comparison
- Cryopreserved vs liquid-stored platelets
- Primary endpoint
- Postsurgical chest drain bleeding (non-inferiority: <20% greater bleeding)
- Follow-up
- First 24 hours after ICU admission
Methodological detailsmulticentre, double-blind, parallel-group, non-inferiority
- Multicentre
- Double-blind
- Parallel-group
- Non-inferiority
Primary result
Chest drain bleeding · 24 hours after ICU admission
Ratio of geometric means
1.13
95% CI 0.96–1.34
P = 0.07
By group
Cryopreserved vs Liquid-stored
ratio of geometric means 1.13 (95% CI 0.96–1.34); P = 0.07
Non-inferiority margin 20 as printed, not drawn
As reported in the abstract
Further findings
| Outcome | Ratio of geometric means (95% CI) | |
|---|---|---|
| Intraoperative and total perioperative blood lossCryopreserved vs Liquid-stored · intraoperative | 1.42 (1.12–1.80) | |
| Intraoperative and total perioperative blood lossCryopreserved vs Liquid-stored · total perioperative | 1.31 (1.07–1.60) | |
| 0.512Ratio of geometric means (log scale) |
Intraoperative and total perioperative blood loss
- Increased red cell, plasma and cryoprecipitate transfusion with cryopreserved platelets
Safety
| Outcome | Cryopreserved | Liquid-stored |
|---|---|---|
| Duration of ventilation, ICU and hospital length of stayIQR in brackets | ||
| Ventilation | 25.5 hours [16.1-77.3] | 23.6 hours [13.1-52.8] |
| ICU stay | 3.8 days [2.0-6.0] | 3.0 days [1.9-4.9] |
| Hospital stay | 10.9 days [7.87-17.0] | 9.1 [6.9-14.9] |
Prespecified adverse events
- No differences in incidence of prespecified adverse events
Original publication
Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial. JAMA. Published 17 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →