Cardiothoracic & vascular anesthesia
Platelet Transfusion in Cardiac Surgery: An Entropy-Balanced, Weighted, Multicenter Analysis
Authors' conclusion
In cardiac surgery patients, perioperative platelet transfusion was associated with reduced operative and 90-day mortality.
Study context
- Population
- Consecutive adults undergoing cardiac surgery, 40 centers, Australian Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database, 2005–2018
- Participants
- 119,132 adults · 40 centers
- Exposure
- Perioperative platelet transfusion vs no platelet transfusion
- Plateletsn = 25,373
- Controlsn = 93,759reference
- Outcome
- Operative mortality (composite of 30-day and in-hospital mortality) and 90-day mortality
Methodological detailsanalysis of prospectively collected registry data, inverse probability of treatment weighting via entropy balancing, multicentre
- Analysis of prospectively collected registry data
- Inverse probability of treatment weighting via entropy balancing
- Multicentre
Main finding
As reported in the abstract
Operative mortality; 90-day mortality
Platelets vs ControlsOdds ratio (99% CI)P value
Operative mortality
0.63(0.47–0.84)
P < 0.000190-day mortality
0.66(0.51–0.85)
P < 0.0001Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Platelet Transfusion in Cardiac Surgery: An Entropy-Balanced, Weighted, Multicenter Analysis. Anesth Analg. Published 21 July 2023. doi:10.
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