Cardiothoracic & vascular anesthesia
Adjunctive Fresh Frozen Plasma Versus Adjunctive Cryoprecipitate in Cardiac Surgery Patients Receiving Platelets for Perioperative Bleeding
Main finding · Operative mortalityResult — go to the resultRelative risk 1.49 95% CI 1.24–1.79Authors' conclusion
In cardiac surgery patients receiving platelets for perioperative bleeding, adjunctive FFP was independently associated with greater morbidity and mortality compared with adjunctive cryoprecipitate.
Study context
- Population
- Cardiac surgery patients who received platelets for perioperative bleeding, Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database, 2005–2021platelet-transfused
- Participants
- 12,889 patients
- Exposure
- Fresh frozen plasma (FFP) vs Cryoprecipitate
- FFPn = 8,764
- Cryoprecipitaten = 4,125reference
- Outcome
- Operative mortality
Methodological detailsinverse probability of treatment weighting with entropy balancing, multi-institutional (58 centers)
- Inverse probability of treatment weighting with entropy balancing
- Multi-institutional (58 centers)
Main finding
As reported in the abstract
Relative risk
1.49
95% CI 1.24–1.79
P < 0.001
FFP vs Cryoprecipitate
RR 1.49 (95% CI 1.24–1.79); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| 1-year mortality | 1.37 (1.13–1.66) | P = 0.001 | |
| AKI | 1.16 (1.02–1.33) | P = 0.024 | |
| All-cause infection | 1.14 (1.02–1.29) | P = 0.026 | |
| 0.512Relative risk (log scale) |
| Outcome | Adjusted mean difference (days) (95% CI) | P value | |
|---|---|---|---|
| ICU LOS | 8.02 (1.72–14.33) | P = 0.013 | |
| −1001020Difference, days (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Adjunctive Fresh Frozen Plasma Versus Adjunctive Cryoprecipitate in Cardiac Surgery Patients Receiving Platelets for Perioperative Bleeding. J Cardiothorac Vasc Anesth. Published 21 December 2024. doi:10.
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