Cardiothoracic & vascular anesthesia
Association of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery
Main finding · 30-day mortalityResult — go to the resultOdds ratio 1.41 99% CI 1.17–1.71Authors' conclusion
In a multicentre, propensity score matched analysis, perioperative FFP transfusion was associated with increased 30-day mortality and had variable associations with secondary clinical outcomes.
Study context
- Population
- Cardiac surgery patients, Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database, 39 centres, 2005 to 2018eligible
- Participants
- 119,138 patients
- Exposure
- Perioperative fresh frozen plasma (FFP) transfusion vs no FFP
- FFPn = 13,131
- Controlsn = 13,131reference
- Outcome
- 30-day mortality
- Follow-up
- 30-day
Methodological detailspropensity-score matched, multicentre registry
- Propensity-score matched
- Multicentre registry
Main finding
As reported in the abstract
Odds ratio
1.41
99% CI 1.17–1.71
P < 0.0001
FFP vs Controls
OR 1.41 (99% CI 1.17–1.71); P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Long-term mortalityNot significant at Holm-Bonferroni α = 0.0004 · propensity score matched | HR 0.92 (99% CI 0.85–1.00) | P = 0.007 | |
| Return to theatre for bleedingPropensity score matched | OR 1.97 (99% CI 1.66–2.34) | P < 0.0001 | |
| Prolonged intubationPropensity score matched | OR 1.15 (99% CI 1.05–1.26) | P < 0.0001 | |
| 0.512Ratio (log scale) |
| Outcome | MD (mL) (99% CI) | P value | |
|---|---|---|---|
| Chest tube drainage (increased)Propensity score matched | 131 (120–141) | P < 0.0001 | |
| −1000100200Difference, mL (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery. Acta Anaesthesiol Scand. Published 11 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →