Detecting heart failure in severe asthma patients using speckle tracking echocardiography
Authors' conclusion
Patients with acute asthma exhibit decreased strain in all cardiac chambers, which remains reduced at the six-month follow-up.
Study context
- Population
- Severe asthma patients, healthy controls and weightlifters, 2006 to 2025
- Participants
- 357 patients
- Exposure
- Severe asthma vs healthy controls and weightlifters
- Controln = 169reference
- Severe asthman = 188
- Outcome
- Acute myocardial dysfunction (strain by speckle tracking echocardiography with velocity vector imaging (VVI))
Methodological detailscontrolled, 6-month follow-up, Median age of asthma patients 58.11 ± 12.97 years, comparable to controls
- Controlled
- 6-month follow-up
- Median age of asthma patients 58.11 ± 12.97 years, comparable to controls
Main finding
As reported in the abstract
RV global longitudinal strain
Controls
- 27.56
± 4.56
Basal weightlifters
- 24.08
± 1.23
After bench press
- 30.88
± 1.02
Severe asthma
- 17.98
± 2.57
P = 0.0001
Observational data: associations, not effects.
Further findings
Factors associated with mortality (multivariate analysis)
| OR (CI) | ||
|---|---|---|
| Right atrial pump strain | 0.457 (0.189–0.746) | |
| 0.20.5125Odds ratio (log scale) |
Mechanical ventilation
| OR (95% CI) | ||
|---|---|---|
| RVGLS | 0.637 (0.248–0.925) | |
| Right atrial pump strain | 0.783 (0.349–0.967) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Control | Basal weightlifters | After bench press | Severe asthma | P value |
|---|---|---|---|---|---|
| LV global longitudinal strain (%)Severe asthma vs Control · across the four groups | - 21.02 (SD 3.28) % | - 19.34 (SD 3.78) % | - 25.21 (SD 9.32) % | - 14.88 (SD 1.27) % | P = 0.012 |
- Factors associated with mortality (multivariate analysis) — Deaths among asthma patients
- 31
Deformity parameters and Speckle Tracking vectorial velocity · 6 months
- Lower deformity parameters and decreased vectorial velocity in all cardiac chambers in asthma patients vs controls
Original publication
Detecting heart failure in severe asthma patients using speckle tracking echocardiography. Crit Care. Published 21 August 2025. doi:10.
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