Detection and Evaluation of Procalcitonin Variants As Diagnostic Tools in Systemic Inflammation
Authors' conclusion
Polyclonal antibodies generated using procalcitonin N-terminal variant peptides as immunogens are suitable for procalcitonin variant assessment. The separate detection of procalcitonin variants may offer additional diagnostic value and can be correlated with organ dysfunction and clinical outcomes in patients with systemic inflammation.
Study context
- Population
- Septic patients with hyperprocalcitonemia
- Participants
- 19 patients
- Exposure
- Full-length procalcitonin (fullPCT) > truncated procalcitonin (truncPCT) vs truncPCT ≥ fullPCT
- Outcome
- Correlations of procalcitonin variants with DPP4 activity and SOFA scores
Methodological detailsassay development, immunoassay-based (indirect sandwich enzyme-linked immunosorbent assay (ELISA))
- Assay development
- Immunoassay-based (indirect sandwich ELISA)
Main finding
As reported in the abstract
truncPCT vs DPP4 activity (Pearson's R)
0.85
P < .001
truncPCT vs SOFA scores (Pearson's R)
−0.56
P = .013
fullPCT vs SOFA scores (Pearson's R)
0.56
P = .013
Observational data: associations, not effects.
Further findings
Hydrocortisone treatment
P = 0.018
| Outcome | fullPCT > truncPCT | truncPCT | P value |
|---|---|---|---|
| SOFA score by predominant PCT variantMean ± SE of the mean | mean 11. 3 (SE 0.8) | — not stated in the abstract | P = 0.003 |
| Norepinephrine dose · first 24 hours after sepsis diagnosisTendency towards higher doses | — not stated in the abstract | mean 0. 1 (SE 0.03) µg/kg/min | P = 0.062 |
| Creatinine | P = 0.019 | ||
| Leukocytes | P = 0.012 |
— not stated in the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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