Hemodynamics, fluids & transfusion
Detection of fluid responsiveness by changes of perfusion index and pleth-variability index during passive leg raising in spontaneously breathing post-surgical patients: a prospective interventional study
Authors' conclusion
In conclusion, PI could be a helpful non-invasive tool for predicting fluid responsiveness during a PLR test in spontaneously breathing patients, though its diagnostic accuracy appears to be moderate.
Study context
- Population
- Spontaneously breathing patients after major abdominal surgery in the ICU of Merano Hospital, Italyenrolled
- Participants
- 47 participants
- Exposure
- Perfusion index (PI) and pleth variability index (PVI) changes during passive leg raising (PLR) in fluid responders vs non-responders
- Respondersn = 23
- Outcome
- Prediction of fluid responsiveness (SV increase ≥ 10% during PLR) by PI and PVI
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Percentage change in PI from baseline to 60 s into PLR · 60 s
Responders
+ 41.2%
Non-responders
+ 11.3%
- PI increase ≥ 23% predicting responders: sensitivity
- 70%
- PI increase ≥ 23% predicting responders: specificity
- 75%
- AUC (ROC)
- 0.74
- Patients inside the grey zone
- 22 (47%)
Observational data: associations, not effects.
Original publication
Detection of fluid responsiveness by changes of perfusion index and pleth-variability index during passive leg raising in spontaneously breathing post-surgical patients: a prospective interventional study. J Clin Monit Comput. Published 7 April 2025. doi:10.
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