Hemodynamics, fluids & transfusion
Variables influencing the prediction of fluid responsiveness: a systematic review and meta-analysis
Authors' conclusion
Prediction of fluid responsiveness in critically and acutely ill patients is strongly influenced by a number of technical and clinical aspects.
Study context
- Population
- Critically ill and acutely ill surgical patients assessed for fluid responsiveness (pulse pressure variation, stroke volume variation, passive leg raising (PLR), end-expiratory occlusion test (EEOT), mini-fluid challenge, tidal volume challenge)
- Participants
- 149 studies
- Comparison
- Adjusted vs unadjusted diagnostic odds ratios of fluid responsiveness predictors by technical and clinical variables
- Outcome
- Variables modifying the operative performance (adjusted DORs) of fluid responsiveness predictors
Methodological detailssubgroup analyses, meta-regression
- Subgroup analyses
- Meta-regression
Pooled result
As reported in the abstract
Variables modifying operative performance of fluid responsiveness predictors
- Technical variables: volume used during fluid loading, method to assess macrovascular flow changes in response to PLR/EEOT, and apneic time during EEOT modified operative performance
- p < 0.05 for all adjusted vs. unadjusted diagnostic odds ratios (DORs)
Original publication
Variables influencing the prediction of fluid responsiveness: a systematic review and meta-analysis. Crit Care. Published 20 September 2023. doi:10.
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