Perioperative medicine & outcomes
Determinants of postoperative complications in high-risk noncardiac surgery patients optimized with hemodynamic treatment strategies: A post-hoc analysis of a randomized multicenter clinical trial
Authors' conclusion
Surgical complications, a lower preoperative hemoglobin concentration, age, and vascular surgery were associated with postoperative complications in a high-risk noncardiac surgery population supported with hemodynamic treatment strategies.
Study context
- Population
- High-risk patients undergoing high-risk noncardiac surgery ≥2 h under GA, supported with hemodynamic treatment strategies341 analysed
- Participants
- 350 patients
- Primary endpoint
- Composite of:
- Major complications
- Death
- Follow-up
- Within seven days following surgery
Methodological detailsmultivariable logistic regression, Operating rooms in four university medical centers and one non-university hospital, December 26, 2018, to September 9, 2021
- Multivariable logistic regression
- Operating rooms in four university medical centers and one non-university hospital, December 26, 2018, to September 9, 2021
Primary result
As reported in the abstract
Factors independently associated with major complications or death (multivariate analysis)
Odds ratio (CI)P value
Age
1.04(1.01–1.06)
P = 0.002Preoperative hemoglobin concentration
0.85(0.75–0.96)
P = 0.012Non-vascular surgery
0.30(0.17–0.53)
P < 0.0001Intraoperative surgical complications
2.08(1.02–4.24)
P = 0.046Further findings
Factors independently associated with postoperative AKI
| OR (CI) | P value | ||
|---|---|---|---|
| Age | 1.04 (1.01–1.08) | P = 0.008 | |
| Preoperative creatinine concentration | 1.01 (1.00–1.01) | P = 0.049 | |
| Non-vascular surgery | 0.36 (0.20–0.66) | P = 0.001 | |
| Intraoperative surgical complications | 3.36 (1.50–7.55) | P = 0.031 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Determinants of postoperative complications in high-risk noncardiac surgery patients optimized with hemodynamic treatment strategies: A post-hoc analysis of a randomized multicenter clinical trial. J Clin Anesth. Published 22 November 2023. doi:10.
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