ICU sedation, delirium & recovery
Developing Models for Complicated Outcomes in Acutely Intoxicated ICU Patients With and Without Toxicity Information
Authors' conclusion
The mean LRS had prognostic value only in the absence of laboratory test results. Both models may aid decision-making regarding the management of acutely intoxicated patients in the ICU.
Study context
- Population
- Adult patients admitted to the ICU with acute intoxication as the main reason for admission for at least 4 hours; seventy-eight ICUs in Europe, Australia, and the Eastern Mediterranean (2020–2023)adult patients admitted to the ICU with acute intoxication
- Participants
- 2,265 patients
- Exposure
- Two prediction models for ICU complications or death: one incorporating laboratory variables ("Laboratory Model") and one including the mean Lethality Risk Score (LRS) ("Expo Model")
- Outcome
- ICU complications or death
Methodological detailsdevelopment of prediction models, internal validation
- Development of prediction models
- Internal validation
Main finding
As reported in the abstract
ICU complications or death
22.5%
Observational data: associations, not effects.
Further findings
| Outcome | Laboratory Model | Expo Model |
|---|---|---|
| Model performance, internal validationMinimal overfitting | ||
| AUROC | 0.79 | 0.77 |
| Calibration slope | 0.94 | 0.95 |
| Intercept | −0.06 | −0.06 |
| Decision curve analysis: clinically relevant threshold probability ranges | 0-50% | 0-40% |
Key predictors
- Key predictors were age, severity at presentation, systolic blood pressure, Glasgow Coma Scale score, and hospital type
- The mean LRS remained significant only when laboratory variables were not considered
Original publication
Developing Models for Complicated Outcomes in Acutely Intoxicated ICU Patients With and Without Toxicity Information. Crit Care Med. Published 15 October 2026. doi:10.
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