ICU sedation, delirium & recovery
The INTOXICATE study: methodology and preliminary results of a prospective observational study
Authors' conclusion
The vast majority of patients survive, and approximately one third of patients do not receive any ICU-specific interventions after admission in an intensive care unit for acute intoxication.
Study context
- Population
- Acutely intoxicated adult ICU patients; 78 intensive care units (ICUs), mainly Europe, also Australia and Eastern Mediterranean, Nov 2020–Jun 2023
- Participants
- 2,273 participants · 78 ICUs
- Outcome
- Eventful admission: composite of any of FiO2 > 40%, mechanical ventilation, vasopressors, renal replacement therapy (RRT), CPR, antidotes, active cooling, fluid resuscitation (> 1.5 L IV fluid), sedation in first 24 h after ICU admission, or in-hospital death
- Follow-up
- First 24 h after ICU admission
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Eventful ICU admission (composite)
Observed rate of eventful ICU admission
68%
n = 1546/2273 patients
Observational data: associations, not effects.
Further findings
Hospital mortality
- Hospital mortality
- 4.5% (n = 103/2273)
Patient characteristics
- Median age (years)
- 41
- Exposed to intoxicating drugs
- 72%
Original publication
The INTOXICATE study: methodology and preliminary results of a prospective observational study. Crit Care. Published 27 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →