Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
Authors' conclusion
The novel Phoenix sepsis criteria, which were derived and validated using data from higher- and lower-resource settings, had improved performance for the diagnosis of pediatric sepsis and septic shock compared with the existing IPSCC criteria.
Study context
- Population
- Children (<18 years) in emergency and inpatient encounters, 10 health systems in the US, Colombia, Bangladesh, China and Kenya, 2010–201910 health systems
- Exposure
- Phoenix sepsis criteria vs 2005 International Pediatric Sepsis Consensus Conference (IPSCC) criteria
- Outcome
- In-hospital mortality (prediction performance: AUPRC primary; PPV and sensitivity for binary criteria)
Methodological detailsmulticentre, international, derivation and external validation, Development set 3 049 699; external validation set 581 317 encounters
- Multicentre
- International
- Derivation and external validation
- Development set 3 049 699; external validation set 581 317 encounters
Main finding
As reported in the abstract
Prediction of in-hospital mortality, validation sets
| Group | Area under the precision recall curve (AUPRC) | AUROC |
|---|---|---|
| Phoenix | 0.23 to 0.38 (95% CI range, 0.20-0.39) | 0.71 to 0.92 (95% CI range, 0.70-0.92) |
Phoenix
Area under the precision recall curve (AUPRC)0.23 to 0.38 (95% CI range, 0.20-0.39)
AUROC0.71 to 0.92 (95% CI range, 0.70-0.92)
Observational data: associations, not effects.
Further findings
Model derivation (development set, suspected infection in first 24 h)
- Mortality in development set
- 1.2%
- 4-organ-system model performed best
- 172 984 children with suspected infection
Original publication
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock. JAMA. Published 27 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →