Respiratory failure & ventilation
Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials
Authors' conclusion
The CVC-IN score, which can be used for the first catheter, had a modest ability to discriminate required catheter dwell time.
Study context
- Population
- Mechanically ventilated critically ill patients requiring central venous catheterizationrestricted to ventilated patients
- Participants
- 2,336 vs 2,371
- Exposure
- CVC-IN score ≥ 4 vs < 4
- Trainingn = 2,336
- Testingn = 2,371
- Outcome
- Required catheter dwell time (first catheter insertion to removal of last catheter for absence of utility)
Methodological detailsprediction model development and validation, data from three multicentre RCTs, competing-risk (subdistribution hazard) analysis, internal validation by 500 bootstraps, external validation
- Prediction model development and validation
- Data from three multicentre RCTs
- Competing-risk (subdistribution hazard) analysis
- Internal validation by 500 bootstraps
- External validation
Main finding
As reported in the abstract
Discrimination of CVC-IN score (AUC) for required catheter dwell time · day 28
| Group | AUC |
|---|---|
| Training | 0.69 (95% CI 0.66-0.72) |
| Testing | 0.64 (95% CI 0.61-0.66) |
AUC
Training0.69 (95% CI 0.66-0.72)
Testing0.64 (95% CI 0.61-0.66)
Observational data: associations, not effects.
Further findings
Median required catheter dwell time by CVC-IN score (overall cohort)
PPV of CVC-IN score ≥ 4 for > 7 days required catheter dwell time (testing cohort)
- PPV
- 76.9%
Original publication
Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials. Ann Intensive Care. Published 16 January 2023. doi:10.
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