ICU sedation, delirium & recovery
Development and validation of potential phenotypes of serum electrolyte disturbances in critically ill patients and a Web-based application
Authors' conclusion
Three different clinical phenotypes were identified that correlated with electrolyte distribution and clinical outcomes.
Study context
- Population
- Critically ill ICU patients with electrolyte records during early ICU stay (MIMIC-IV, eICU-CRD, AmsterdamUMCdb)15,340 MIMIC-IV
- Exposure
- Electrolyte phenotypes α, β and γ
- Outcome
- 28-day mortality and ICU LOS by phenotype
Methodological detailsdata-driven phenotyping (K-means clustering), training and validation sets, three public databases, Assignment methods developed into a web-based tool
- Data-driven phenotyping (K-means clustering)
- Training and validation sets
- Three public databases
- Assignment methods developed into a web-based tool
Main finding
As reported in the abstract
- α and γ phenotypes: higher 28-day mortality and longer ICU LOS
- p < 0.001
Observational data: associations, not effects.
Original publication
Development and validation of potential phenotypes of serum electrolyte disturbances in critically ill patients and a Web-based application. J Crit Care. Published 28 March 2024. doi:10.
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