Diagnostic Performance of Point-of-Care Immunoassay Measurements of Pancreatic Stone Protein for Sepsis Detection in ICU Patients: A Prospective, Multicenter, Biomarker-Blinded Study
Authors' conclusion
PSP can serve as a biomarker for the early identification of sepsis.
Study context
- Population
- Adults in 6 US ICUs expected to require ≥24 hours of ICU care
- Participants
- 466 adults · 6 ICUs
- Comparison
- Point-of-care pancreatic stone protein (PSP) immunoassay for sepsis detection
- Outcome
- Diagnostic performance of PSP for early sepsis identification
- Follow-up
- First three days of ICU admission
Methodological detailsmulticentre, prospective, observational, biomarker-blinded
- Multicentre
- Prospective
- Observational
- Biomarker-blinded
Performance
As reported in the abstract
Sepsis detection
| Test or model | Cutoff | Sensitivity | Specificity | Accuracy | PPV | NPV | LR+ | Likelihood ratio (LR-) |
|---|---|---|---|---|---|---|---|---|
| PSP | 117 ng/mL | 74.2% | 67.8% | 71.0% | 70.3% | 71.9% | 2.30 | 0.38 |
| PSP + C-reactive protein (CRP) | 95.2% |
Cutoff
PSP117 ng/mL
PSP + C-reactive protein (CRP)— not stated in the abstract
Sensitivity
PSP74.2%
PSP + C-reactive protein (CRP)— not stated in the abstract
Specificity
PSP67.8%
PSP + C-reactive protein (CRP)95.2%
Accuracy
PSP71.0%
PSP + C-reactive protein (CRP)— not stated in the abstract
PPV
PSP70.3%
PSP + C-reactive protein (CRP)— not stated in the abstract
NPV
PSP71.9%
PSP + C-reactive protein (CRP)— not stated in the abstract
LR+
PSP2.30
PSP + C-reactive protein (CRP)— not stated in the abstract
Likelihood ratio (LR-)
PSP0.38
PSP + C-reactive protein (CRP)— not stated in the abstract
Further findings
| Outcome | PSP |
|---|---|
| Febrile patients (subgroup) | |
| Specificity | 77.8% |
| Sensitivity | 63.6% |
| Non-febrile patients (subgroup) | |
| Specificity and sensitivity (as printed, order ambiguous) | 67.0% and 76.6% |
- Non-febrile patients (subgroup): abstract prints "specificity and sensitivity sensitivity and specificity were 67.0% and 76.6%"
Subgroups by sex and age (subgroup)
- Consistent performance across sex; higher specificity in patients 18-60 years old
Original publication
Diagnostic Performance of Point-of-Care Immunoassay Measurements of Pancreatic Stone Protein for Sepsis Detection in ICU Patients: A Prospective, Multicenter, Biomarker-Blinded Study. Crit Care Med. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →