Serial monitoring of pancreatic stone protein for the detection of sepsis in intensive care unit patients with complicated abdominal surgery: A prospective, longitudinal cohort study
Authors' conclusion
Serial PSP monitoring may be an additional tool for the early detection of sepsis in patients with complicated abdominal surgery who are at high risk of severe infections.
Study context
- Population
- Intensive care unit (ICU) patients with complicated abdominal surgery68 patients · 118 episodes
- Participants
- 118 vs 73
- Exposure
- PSPmax and ΔPSP for detection of sepsis
- PSPmax ≥124 ng/mln = 118
- ΔPSP ≥34 ng/mln = 73
- Outcome
- Performance of PSP monitoring for detection of sepsis
Methodological detailsmulticentre, longitudinal, serial measurements
- Multicentre
- Longitudinal
- Serial measurements
Main finding
As reported in the abstract
Detection of sepsis
| Strategy | Sensitivity | Specificity |
|---|---|---|
| PSPmax ≥124 ng/ml | 84% | 54% |
| ΔPSP ≥34 ng/ml | 69% | 76% |
Sensitivity
PSPmax ≥124 ng/ml84%
ΔPSP ≥34 ng/ml69%
Specificity
PSPmax ≥124 ng/ml54%
ΔPSP ≥34 ng/ml76%
Observational data: associations, not effects.
Further findings
Prediction of outcome (fatal outcome)
- PSPmax and ΔPSP significantly higher in patients with a fatal outcome
Bacterial/mixed vs fungal infections
- No significant difference of PSPmax or ΔPSP between bacterial/mixed vs fungal infections
Original publication
Serial monitoring of pancreatic stone protein for the detection of sepsis in intensive care unit patients with complicated abdominal surgery: A prospective, longitudinal cohort study. J Crit Care. Published 11 March 2024. doi:10.
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