ICU sedation, delirium & recovery
Differences in long-term outcomes between ICU patients with persistent delirium, non-persistent delirium and no delirium: A longitudinal cohort study
Main finding · Long-term cognitive impairmentResult — go to the resultAdjusted odds ratio 3.90 95% CI 1.31–11.63Authors' conclusion
Patients with PD had a higher likelihood to develop cognitive impairment 1-year post-ICU compared to NPD or ND. Patients with PD and NPD were more likely to experience impairment on all health domains (i.e. physical, mental and cognitive), compared to ND patients.
Study context
- Population
- Adult ICU patients of two hospitals admitted July 2016–February 2020completed both questionnaires
- Participants
- 2,400 patients
- Exposure
- Persistent delirium vs non-persistent delirium vs no delirium
- PDn = 35
- Non-persistent delirium (NPD)n = 494
- Outcome
- Physical, mental and cognitive outcomes (questionnaires on health, frailty and QoL)
- Follow-up
- 1-year post-ICU
Methodological detailstwo hospitals
- Two hospitals
Main finding
Long-term cognitive impairment
Adjusted odds ratio
3.90
95% CI 1.31–11.63
PD vs ND
aOR 3.90 (95% CI 1.31–11.63)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | PD | NPD | P value |
|---|---|---|---|
| Frailty · 1-year post-ICUPD vs NPD | 34.3% | 14.6% | P = 0.006 |
| Fatigue · 1-year post-ICUPD vs NPD | 85.7% | 61.1% | P = 0.012 |
Original publication
Differences in long-term outcomes between ICU patients with persistent delirium, non-persistent delirium and no delirium: A longitudinal cohort study. J Crit Care. Published 18 February 2023. doi:10.
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