Cardiac arrest & resuscitation
Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness: Insights From Two International Data Sets
Authors' conclusion
TTM32-36 was significantly associated with a better outcome in patients with low and high severity at ICU admission assessed according to the mCAHP score.
Study context
- Population
- Comatose patients after OHCA, Sudden Death Expertise Center (SDEC) registry (France, 2011–2017) and Resuscitation Outcomes Consortium Continuous Chest Compressions (ROC-CCC) trial (US and Canada, 2011–2015)2,723 SDEC
- Exposure
- TTM32-36 vs no TTM32-36, by mCAHP severity tertile at ICU admission
- Outcome
- Favorable neurologic status at hospital discharge
- Follow-up
- Hospital discharge
Methodological detailssubgroup analysis by severity tertiles, multiple logistic regression, two data sets (SDEC registry, ROC-CCC trial)
- Subgroup analysis by severity tertiles
- Multiple logistic regression
- Two data sets (SDEC registry, ROC-CCC trial)
Main finding
As reported in the abstract
Favorable neurologic status by mCAHP severity tertile (subgroups)
TTM32-36Adjusted odds ratio (95% CI)P value
SDEC, low severity
1.63(1.15–2.30)
P = 0.006SDEC, high severity
1.94(1.06–3.54)
P = 0.030ROC-CCC, low severity
1.36(1.05–1.75)
P = 0.020ROC-CCC, high severity
2.42(1.38–4.24)
P = 0.002Observational data: associations, not effects.
Further findings
Favorable neurologic status at hospital discharge, overall
- SDEC data set
- 728 (27%)
- ROC-CCC data set
- 1,239 (29%)
Original publication
Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness: Insights From Two International Data Sets. Chest. Published 30 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →