Pediatric anesthesia & critical care
Differential effects of propofol anaesthesia across three amplitude-defined electroencephalographic states in sedated critically ill term neonates: An observational study
Authors' conclusion
The data suggest that propofol anaesthesia increases isoelectric EEG states while also reducing the spectral power, specifically during low-voltage EEG states.
Study context
- Population
- Critically ill term neonates (postmenstrual age 37 to 44 weeks) in intensive care requiring anaesthesia for noncardiac surgery17 analysed
- Participants
- 20 neonates
- Exposure
- Before induction vs during 20-min continuous rate propofol infusion
- Outcome
- Time occupancy and spectral properties within amplitude-defined EEG states (isoelectric <10 μV, low-voltage 10 to 25 μV, high-voltage >25 μV; 1 s epochs)
Main finding
As reported in the abstract
Time spent in isoelectric state per patient
P < 0.002
- Low-voltage state present: 16/17 (94%) before vs 17/17 (100%) during propofol
- P < 0.001
- Isoelectric state present: 2/17 (70.5%) before vs 16/17 (94.1%) during propofol
- P = 0.016
- Reduced spectral power across all frequency bands during low-voltage states
- all P < 0.026
Observational data: associations, not effects.
Further findings
| Outcome | Rho (95% CI) | P value |
|---|---|---|
| Correlation of gestational age with time in isoelectric state | −0.539 (−0.11 to −0.87) | P = 0.031 |
Original publication
Differential effects of propofol anaesthesia across three amplitude-defined electroencephalographic states in sedated critically ill term neonates: An observational study. Eur J Anaesthesiol. Published 23 May 2025. doi:10.
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