Respiratory failure & ventilation
Digital Twins to Evaluate the Risk of Ventilator-Induced Lung Injury During Airway Pressure Release Ventilation Compared With Pressure-Controlled Ventilation
Authors' conclusion
Using digital twins we found possible lung-protective conditions and beneficial effects of APRV which need further evaluation in randomized clinical trials.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS) receiving pressure-controlled ventilation (PCV) (digital twins from ventilator settings and arterial blood gases)
- Participants
- 98 digital twins
- Comparison
- Airway pressure release ventilation (APRV) vs PCV in the same digital twins
- Outcome
- Key indices of ventilator-induced lung injury (VILI)
Methodological detailsdigital twins, high-fidelity cardiopulmonary simulation model, global optimization algorithms
- Digital twins
- High-fidelity cardiopulmonary simulation model
- Global optimization algorithms
Main finding
As reported in the abstract
VILI indices, APRV vs PCV
Mean mechanical power (MP) reduced with APRV vs PCV
32%
Mean tidal alveolar recruitment/de-recruitment reduced with APRV vs PCV
34%
Further findings
| Outcome | APRV | PCV |
|---|---|---|
| Gas exchange | mean 58.5 mm Hg | 45.6 mm Hg |
| pHa | 7.32 | 7.37 |
- Gas exchange: PaCO2; moderate hypercapnia with APRV
Computational optimization of APRV settings
- Settings close to optimal for minimizing mean MP and mean tidal recruitment/de-recruitment during APRV
Original publication
Digital Twins to Evaluate the Risk of Ventilator-Induced Lung Injury During Airway Pressure Release Ventilation Compared With Pressure-Controlled Ventilation. Crit Care Med. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →