Perioperative medicine & outcomes
Diminished rest–activity rhythm is associated with postoperative complications and mortality: A prospective cohort study of UK Biobank participants
Authors' conclusion
A lower preoperative circadian relative amplitude is associated with increased postoperative morbidity and mortality.
Study context
- Population
- Adults (37 to 73 years) in UK Biobank undergoing major surgery within 1 year of 7-day preoperative wrist accelerometry
- Participants
- 5,654 adults
- Exposure
- Low vs high preoperative rest-activity rhythm relative amplitude
- Low relative amplituden = 225
- High relative amplituden = 5,429reference
- Outcome
- Composite of:
- 30-day postoperative complications
- 90-day mortality
Methodological detailspopulation-based cohort, UK Biobank
- Population-based cohort
- UK Biobank
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Each SD decrease in relative amplitudedose-response; continuous analysis
1.23(1.06–1.42)
Each SD decrease in relative amplitude, as printed
- Low relative amplitude vs High relative amplitude
- absolute risk difference 6.1%; P < 0.001
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diminished rest–activity rhythm is associated with postoperative complications and mortality: A prospective cohort study of UK Biobank participants. Eur J Anaesthesiol. Published 20 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →