Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock
Primary result · 30-day mortalityResult — go to the resultAdjusted odds ratio 0.26 95% CI 0.09–0.80Authors' conclusion
Despite greater illness severity, AKI-resistant patients had similar mortality and length of stay as lower-risk patients but better outcomes than those with AKI.
Study context
- Population
- Patients with septic shock enrolled in the ProCESS trial
- Participants
- 573 patients
- Comparison
- Acute kidney injury (AKI)-resistant vs AKI vs reduced risk
- AKI-resistantn = 40
- AKIn = 194reference
- Reduced riskn = 339
Methodological detailsretrospective analysis
- Retrospective analysis
Primary result
30-day mortality · 30 days
Adjusted odds ratio
0.26
95% CI 0.09–0.80
P = 0.02
By group
AKI-resistant vs AKI
aOR 0.26 (95% CI 0.09–0.80); P = 0.02
As reported in the abstract
Further findings
Median
| Outcome | AKI-resistant | AKI | Reduced risk | P value |
|---|---|---|---|---|
| Non-renal SOFA scoreReduced risk vs AKI-resistant | 6 (IQR 4.5–8) | 6 (IQR 5–9) | 5 (IQR 2–7) | P < 0.01 |
| Non-renal SOFA scoreReduced risk vs AKI | P < 0.01 |
ICU stay
- Shorter ICU stays in AKI-resistant vs AKI
Baseline characteristics
- Did not differ between AKI-resistant and AKI
Original publication
Discovery of a resistant cohort to acute kidney injury: insights from patients with septic shock. Crit Care. Published 8 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →