Clinical outcomes of persistent sepsis-associated acute kidney injury in septic shock: a post-hoc analysis of a multicenter prospective cohort study
An erratum to this article was published (Ann Intensive Care, 24 Apr 2026 ↗)
Primary result · 90-day mortalityResult — go to the resultAdjusted hazard ratio 2.75 95% CI 1.39–5.42Authors' conclusion
In patients with septic shock requiring high-dose norepinephrine, persistent SA-AKI is associated with worse clinical outcomes.
Study context
- Population
- Patients with septic shock requiring high-dose norepinephrine in 20 ICUs
- Participants
- 257 patients · 20 ICUs
- Comparison
- Persistent vs transient sepsis-associated acute kidney injury (SA-AKI)
- Persistent SA-AKIn = 111
Primary result
90-day mortality · 90 days
Adjusted hazard ratio
2.75
95% CI 1.39–5.42
P = 0.004
Persistent SA-AKI vs Transient SA-AKI
aHR 2.75 (95% CI 1.39–5.42); P = 0.004
As reported in the abstract
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Hospital mortality | 4.29 (1.87–10.70) | P < 0.001 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Risk factor for persistent SA-AKI: time-weighted average vasoactive-inotropic score
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Greater time-weighted average vasoactive-inotropic score | 1.03 (1.01–1.06) | P = 0.03 | |
| 0.512Adjusted odds ratio (log scale) |
Incidence of SA-AKI and persistent SA-AKI · within 48 h of ICU admission
- Developed SA-AKI
- 215 (84%)
- Progressed to persistent SA-AKI
- 111 (43%)
Original publication
Clinical outcomes of persistent sepsis-associated acute kidney injury in septic shock: a post-hoc analysis of a multicenter prospective cohort study. Ann Intensive Care. Published 27 February 2026. doi:10.
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