Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study
Authors' conclusion
In patients with septic shock, early administration of PMX-HP was associated with higher mean arterial pressure and lower VIS within 48 h after ICU admission.
Study context
- Population
- Adults with septic shock requiring high-dose norepinephrine (≥ 0.2 μg/kg/min) treated with polymyxin B hemoperfusion (PMX-HP)of 309 in registry
- Participants
- 82 adults
- Exposure
- Early vs late administration of PMX-HP
- Early administrationn = 40
- Late administrationn = 42reference
- Outcome
- Short-term hemodynamic status: MAP and vasoactive-inotropic score (VIS)
- Follow-up
- Within 48 h after ICU admission
Methodological detailsBEAT-SHOCK registry
- BEAT-SHOCK registry
Main finding
As reported in the abstract
MAP and VIS within 48 h
- MAP significantly higher at 6 h and 8 h in the Early administration group
- Vasoactive-inotropic score (VIS) significantly lower at 8 h and thereafter in the Early administration group
- Median time to PMX-HP 265 min (IQR 113-480)
Observational data: associations, not effects.
Further findings
Vasopressor/inotrope-free days · 28 days
P = 0.027
ICU-free days · 28 days
P = 0.025
| Outcome | Early administration | Late administration | aHR (95% CI) | |
|---|---|---|---|---|
| Cumulative mortality · 90 days | 15.3% | 31.3% | 0.38 (0.13–1.09) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study. Crit Care. Published 9 May 2025. doi:10.
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