Perioperative medicine & outcomes
Does Autologous Platelet-Rich Plasma Improve Blood Conservation and Postoperative Outcomes in Acute Type A Aortic Dissection Surgery? A Systematic Review and Meta-Analysis
Authors' conclusion
In ATAAD surgery, aPRP may reduce transfusion needs, reoperations, and ventilation duration without increasing adverse outcomes.
Study context
- Population
- Adults undergoing emergency surgery for acute type A aortic dissection (ATAAD)
- Participants
- 2,150 adults · 6 studies
- Comparison
- Intraoperative autologous platelet-rich plasma (aPRP) vs no aPRP during ATAAD repair
- aPRPn = 906
- Outcome
- Reoperation for bleeding and allogeneic blood product transfusion volumes
Methodological detailssubgroup analysis of RCT and propensity-matched data
- Subgroup analysis of RCT and propensity-matched data
Pooled result
As reported in the abstract
Reoperation; platelet and cryoprecipitate transfusion
aPRP vs No aPRPOdds ratio (95% CI)P value
Reoperation rates
0.4(0.2–0.7)
P = 0.005aPRP vs No aPRPMD, units (95% CI)P value
Platelet use
−2.2(−3.5 to −0.9)
P = 0.001Cryoprecipitate use
−1.9(−3.0 to −0.8)
P < 0.001Further pooled results
| Outcome | MD (hours) (95% CI) | P value | |
|---|---|---|---|
| Mechanical ventilation time | −13.8 (−23.9 to −3.7) | P = 0.008 | |
| −30−20−10010Difference, hours (linear scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Prolonged ventilation | 0.3 (0.2–0.7) | P = 0.004 | |
| 0.20.5125Odds ratio (log scale) |
Mortality and hospital stay
- No differences observed
Plasma transfusion volumes (RCT and propensity-matched subgroup)
- Reduced with aPRP
Safety
Neurological or renal complications
- No differences observed
Original publication
Does Autologous Platelet-Rich Plasma Improve Blood Conservation and Postoperative Outcomes in Acute Type A Aortic Dissection Surgery? A Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 18 September 2025. doi:10.
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