Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis
Authors' conclusion
Our simulated dosing regimen achieved therapeutic concentrations more successfully in patients with obesity.
Study context
- Population
- Patients with BMI ≥ 30 kg.m-2 undergoing elective laparoscopic abdominal surgery221 plasma samples
- Participants
- 30 patients
- Comparison
- Doses used currently vs Simulated regimen
- Outcome
- Probability of target attainment of therapeutic plasma lidocaine concentration 2.5–5 μg.ml-1 (simulated)
Methodological detailsdosing simulations
- Dosing simulations
Main finding
As reported in the abstract
Probability of target attainment (plasma concentration 2.5–5 μg.ml-1), simulated
- Unbound lidocaine volume of distribution
- 2.1 l.kg-1
- Unbound lidocaine clearance
- 1.7 l.kg-1.h-1
Further findings
Unbound lidocaine PK parameters (four-compartment model)
- Volume of distribution (l.kg-1)
- 2.1
- Clearance (l.kg-1.h-1)
- 1.7
Original publication
Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis. Anaesthesia. Published 2 January 2025. doi:10.
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