Perioperative medicine & outcomes
A double-blind, randomised, placebo-controlled trial comparing intrathecal bupivacaine with bupivacaine plus morphine to reduce delirium in patients with hip fractures—Salmon-Mind trial study protocol
Study context
- Population
- Patients with a proximal femur fracture scheduled for surgery under spinal anaesthesia
- Planned comparison
- Intrathecal bupivacaine plus morphine vs bupivacaine alone
- Primary endpoint
- Incidence of delirium
- Follow-up
- During hospital admission
Methodological detailsdouble-blind, placebo-controlled, Secondary objectives: pain scores, systemic opioid consumption, (opioid-related) side-effects; tertiary: association of intrathecal morphine with serum neurofilament light
- Double-blind
- Placebo-controlled
- Secondary objectives: pain scores, systemic opioid consumption, (opioid-related) side-effects; tertiary: association of intrathecal morphine with serum neurofilament light
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
A double-blind, randomised, placebo-controlled trial comparing intrathecal bupivacaine with bupivacaine plus morphine to reduce delirium in patients with hip fractures—Salmon-Mind trial study protocol. BJA Open. Published 20 July 2023. doi:10.
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