Perioperative medicine & outcomes
Preoperative low-dose dexmedetomidine reduces postoperative delirium in elderly patients with hip fracture under spinal anesthesia: A randomized, double blind, controlled clinical study
Authors' conclusion
In patients aged ≥65 years undergoing elective hip fracture surgery under spinal anesthesia, continuous overnight administration of low-dose dexmedetomidine improved sleep quality on the night before surgery and reduced the incidence of POD.
Study context
- Population
- Patients aged ≥65 years with hip fracture scheduled for surgical repair under spinal anaesthesia233 in modified ITT analysis
- Participants
- 248 patients
- Comparison
- Preoperative low-dose dexmedetomidine overnight vs placebo
- Dexmedetomidinen = 124
- Placebon = 124reference
- Primary endpoint
- Incidence of POD
- Follow-up
- Between postoperative days 1 and 7 or at hospital discharge
Methodological detailsdouble blind, placebo-controlled, single-centre
- Double blind
- Placebo-controlled
- Single-centre
Primary result
As reported in the abstract
P = 0.014
Secondary outcomes
| Outcome | P value |
|---|---|
| Preoperative sleep quality (LSEQ, ISI)Dexmedetomidine vs Placebo · higher LSEQ scores | P < 0.001 |
| Preoperative sleep quality (LSEQ, ISI)Dexmedetomidine vs Placebo · lower ISI scores | P < 0.001 |
| Postoperative CRPLower CRP levels | P < 0.001 |
Other secondary outcomes
- No differences between the two groups
Safety
Perioperative adverse events
- No differences between the two groups
Original publication
Preoperative low-dose dexmedetomidine reduces postoperative delirium in elderly patients with hip fracture under spinal anesthesia: A randomized, double blind, controlled clinical study. J Clin Anesth. Published 12 June 2025. doi:10.
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