Cardiothoracic & vascular anesthesia
Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial
Authors' conclusion
In patients recovering from an elective cardiac surgery, an overnight infusion of dexmedetomidine did not decrease postoperative delirium.
Study context
- Population
- Adults aged 65 years or older requiring elective cardiac surgery331 analysed
- Participants
- 333 adults
- Comparison
- Overnight dexmedetomidine infusion vs placebo after cardiac surgery
- Dexmedetomidinen = 165
- Placebon = 166reference
- Primary endpoint
- Occurrence of PoD
- Follow-up
- Within 7 days after surgery
Methodological detailspragmatic, multicentre, double-blind, placebo-controlled
- Pragmatic
- Multicentre
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
P = 0.97
Further findings
Functional outcomes (Short-form 36, Cognitive failure questionnaire, PCL-5) · 3 months
- Comparable between the two groups
Safety
Hypotensive events · significantly more with dexmedetomidine
P < 0.01
Original publication
Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial. Crit Care. Published 29 February 2024. doi:10.
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