Perioperative medicine & outcomes
Duration of Intraoperative Cerebral Oxygen Desaturation and Postoperative Delirium in Elderly Patients Undergoing Major Noncardiac Surgery: A Prospective Observational Study
Main finding · PODResult — go to the resultAdjusted odds ratio 1.05 95% CI 1.01–1.09Authors' conclusion
Prolonged intraoperative cerebral oxygen desaturation is independently associated with POD in elderly noncardiac surgical patients.
Study context
- Population
- Patients aged ≥65 years undergoing major noncardiac surgery
- Participants
- 347 patients
- Exposure
- Cumulative duration of intraoperative rSO₂ decline ≥20% from baseline and postoperative delirium (POD)
- Outcome
- POD (Confusion Assessment Method, twice daily)
- Follow-up
- 5 postoperative days
Methodological detailssingle-center
- Single-center
Main finding
POD
Adjusted odds ratio
1.05
95% CI 1.01–1.09
P = 0.012
Each additional minute of rSO₂ decline ≥20%
aOR 1.05 (95% CI 1.01–1.09); P = 0.012
Each additional minute of rSO₂ decline ≥20%, as printed
As reported in the abstract
- POD incidence
- 83 of 347 (23.9%)
Observational data: associations, not effects.
Further findings
Other independent predictors of POD
| aOR | |
|---|---|
| Age | 1.09 |
| Preoperative Mini-Mental State Examination score | 0.79 |
| Surgical duration | 1.01 |
Model discrimination and reclassification
- Full model AUC
- 0.743
- Category-free net reclassification improvement from adding rSO₂ decline duration
- 0.207 (p = 0.038)
Original publication
Duration of Intraoperative Cerebral Oxygen Desaturation and Postoperative Delirium in Elderly Patients Undergoing Major Noncardiac Surgery: A Prospective Observational Study. J Cardiothorac Vasc Anesth. Published 1 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →