Perioperative medicine & outcomes
Excessive Anesthetic Depth Is Associated With Increased Rate of Postoperative Delirium After Cardiac Surgery: A Retrospective Analysis of Processed Electroencephalography
Authors' conclusion
Exposure below the recommended anesthetic depth threshold (PSI of 25), measured by both duration and cumulative area, was a significant risk factor for POD after cardiac surgery.
Study context
- Population
- Adults (≥ 18 years) undergoing cardiac surgery with CPB, university hospital in Sweden, January 2021–February 2024; complex procedures and major perioperative complications excluded
- Participants
- 733 adults
- Exposure
- Exposure to Patient State Index (PSI) < 25 and postoperative delirium (POD)
- Outcome
- POD
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Association of PSI < 25 exposure with POD (multivariable logistic regression)
Adjusted odds ratio (95% CI)
PSI duration < 25 (per 10-minute increase)
1.04(1.01–1.06)
PSI area < 25 (per 10-unit increase)
1.01(1.00–1.01)
Each row per its own increment, as printed
- POD incidence
- 18.1%
Observational data: associations, not effects.
Further findings
Risk stratification by PSI threshold < 25
- POD, low-risk group
- 12%
- POD, high-risk group
- >30%
Sensitivity analyses
- PSI < 25 robust as predictor; thresholds of 20 and 30 showed weaker associations
Original publication
Excessive Anesthetic Depth Is Associated With Increased Rate of Postoperative Delirium After Cardiac Surgery: A Retrospective Analysis of Processed Electroencephalography. J Cardiothorac Vasc Anesth. Published 2 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →