Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis
Pooled resultResult — go to the resultPooled odds ratio 0.78 95% CI 0.60–1.00Authors' conclusion
Our primary analysis demonstrated a highly sensitive result with a pooled analysis of trials in which the intervention group adhered to manufacturer's recommended guidelines, showing reduced incidence of POD with pEEG guidance.
Study context
- Population
- Adults having GA for any surgery (sedation and intensive care settings excluded)
- Participants
- 4,648 adults · 9 studies
- Comparison
- Processed electroencephalography (pEEG)-guided GA or lighter pEEG target vs usual care or deeper pEEG target
- pEEG-guided GA or lighter pEEG targetn = 2,310
- Usual care or deeper pEEG targetn = 2,338reference
- Outcome
- Postoperative delirium (POD) assessed by validated tools
Methodological detailsupdated, prospectively registered
- Updated
- Prospectively registered
Pooled result
As reported in the abstract
Pooled odds ratio
0.78
95% CI 0.60–1.00
P = 0.054
Events by group
pEEG-guided GA or lighter pEEG target vs Usual care or deeper pEEG target
pooled OR 0.78 (95% CI 0.60–1.00); P = 0.054
Original publication
Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis. Br J Anaesth. Published 17 February 2022. doi:10.
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