Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial
Primary result · 28-day mortality, high-risk (mNUTRIC ≥5)Result — go to the resultHazard ratio 0.588 95 % CI 0.388–0.891Authors' conclusion
Early energy delivery ≥60 % of target is linked to lower 28-day mortality in high-risk sepsis patients, with no clear benefit in low-risk groups.
Study context
- Population
- Intensive care units (ICU) patients with sepsis and ≥ 7-day stays183 (15.7 %) died by day 28
- Participants
- 1,162 patients
- Comparison
- ≥60 % vs <60 %
- Primary endpoint
- 28-day all-cause mortality
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Primary result
28-day mortality, high-risk (mNUTRIC ≥5)
Hazard ratio
0.588
95 % CI 0.388–0.891
≥60 % vs <60 %
HR 0.588 (95 % CI 0.388–0.891)
As reported in the abstract
Further findings
Subgroup analyses (subgroup)
- No significant interactions in subgroup analyses
Mortality risk vs energy delivery, high-risk (restricted cubic spline)
- Downward trend in mortality risk with increasing energy delivery
- P-nonlinear = 0.063
Original publication
Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial. J Crit Care. Published 18 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →