Early hemodynamic response to angiotensin II defines a prognostic phenotype in bloodstream infection–associated septic shock
Authors' conclusion
Greater reductions in vasopressor requirements following angiotensin II initiation were strongly associated with improved survival in bloodstream infection-associated septic shock.
Study context
- Population
- Adults with bloodstream infection-associated septic shock treated with angiotensin II, 2019–2025
- Participants
- 320 adults
- Exposure
- Magnitude of early hemodynamic response
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological details3-h landmark analysis, multivariable logistic regression
- 3-h landmark analysis
- Multivariable logistic regression
Main finding
As reported in the abstract
30-day mortality per 10% reduction in NED at 3 h
aOR per 10% reduction in norepinephrine-equivalent dose (NED) at 3 h
0.83
95% CI 0.76–0.90; p < 0.001
aHR per 10% reduction in NED at 3 h, 3-h landmark Cox model
0.89
95% CI 0.85–0.92; p < 0.001
Observational data: associations, not effects.
Further findings
Sensitivity analyses (absolute NED reduction; angiotensin II included in total vasopressor burden)
- Findings consistent
Original publication
Early hemodynamic response to angiotensin II defines a prognostic phenotype in bloodstream infection–associated septic shock. J Crit Care. Published 13 August 2026. doi:10.
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