Cardiac arrest & resuscitation
Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest
Main finding · Survival to hospital dischargeResult — go to the resultAdjusted odds ratio 1.73 95% CI 1.10–2.71Authors' conclusion
In this single-center before-and-after implementation study, an initial IM dose of adrenaline as an adjunct to standard care was associated with improved survival to hospital admission, survival to hospital discharge, and functional survival.
Study context
- Population
- Adult, nontraumatic out-of-hospital cardiac arrest (OHCA) meeting criteria for adrenaline use; single urban two-tiered EMS agency, 2010–2024
- Participants
- 1,405 participants
- Comparison
- Intramuscular (IM) adrenaline vs Standard care
- IM adrenalinen = 420
- Standard caren = 985reference
- Outcome
- Survival to hospital discharge
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Adjusted odds ratio
1.73
95% CI 1.10–2.71
By group
IM adrenaline vs Standard care
aOR 1.73 (95% CI 1.10–2.71)
Secondary outcomes
Time from EMS arrival to first adrenaline dose
| Outcome | IM adrenaline | Standard care | aOR (95% CI) | |
|---|---|---|---|---|
| Survival to hospital admission | 37.1% | 31.6% | 1.37 (1.06–1.77) | |
| Favorable neurologic status at hospital discharge | 9.8% | 6.2% | 1.72 (1.07–2.76) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest. Resuscitation. Published 9 June 2024. doi:10.
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