Cardiac arrest & resuscitation
Vasopressin and steroids in addition to adrenaline in cardiac arrest (VAST-A) – A randomised pilot study
Authors' conclusion
In this IHCA pilot study, randomisation to adrenaline, vasopressin, and corticosteroids compared to controls was safe, but feasibility needs improvement for adequate enrolment in the VAST-A main study.
Study context
- Population
- Witnessed in-hospital cardiac arrest (IHCAs) meeting criteria for adrenaline, three Swedish hospitals183 IHCAs screened
- Participants
- 39 participants
- Comparison
- Adrenaline, vasopressin and corticosteroids vs adrenaline and placebo
- Interventionn = 16
- Controln = 23reference
- Primary endpoint
- Feasibility (e.g., protocol adherence, event times, enrolment rate) and safety
Methodological detailspilot, double-blind, placebo-controlled, multicentre, December 2022 to June 2024, three Swedish hospitals; randomised 1:1
- Pilot
- Double-blind
- Placebo-controlled
- Multicentre
- December 2022 to June 2024, three Swedish hospitals; randomised 1:1
Primary result
As reported in the abstract
Feasibility
| Group | Value | Time to vasopressin/placebo |
|---|---|---|
| Intervention | median 7:00 (IQR 3:00-10:00) minutes | 10:30 (IQR 9:30-12:15) |
| Control | median 5:00 (IQR 2:30-8:30) minutes | 9:00 (IQR 5:00-11:00) |
Value
Interventionmedian 7:00 (IQR 3:00-10:00) minutes
Controlmedian 5:00 (IQR 2:30-8:30) minutes
Time to vasopressin/placebo
Intervention10:30 (IQR 9:30-12:15)
Control9:00 (IQR 5:00-11:00)
- Enrolment rate (patients/hospital bed/month)
- 0.8
- Protocol deviations at the scene of the arrest (patients)
- 4
- Protocol deviations in the ICU (patients)
- 3
Secondary outcomes
ROSC
Original publication
Vasopressin and steroids in addition to adrenaline in cardiac arrest (VAST-A) – A randomised pilot study. Resuscitation. Published 26 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →