Early mobilization with or without cycloergometry in patients with septic shock in Intensive Care Unit: a randomized controlled trial
Authors' conclusion
Although the planned number of patients could not be included, a non-significant signal for decreased ICU LOS was observed in patients who received cycloergometry in at least one phase, in post-hoc analysis. Furthermore, cycloergometry was associated with a significantly lower duration of artificial ventilation.
Study context
- Population
- Sedated-ventilated patients admitted to intensive care unit (ICU) for septic shockinstead of 234 planned
- Participants
- 119 patients
- Comparison
- C+standard physiotherapy (SP) vs SP
- Primary endpoint
- ICU length of stay (LOS), assessed in two phases: phase I hemodynamic stability to first awakening; phase II first awakening to ICU discharge
Methodological detailsprospective, multicentre, two-phase randomisation, Recruitment December 2016 to March 2020; planned sample not reached
- Prospective
- Multicentre
- Two-phase randomisation
- Recruitment December 2016 to March 2020; planned sample not reached
Primary result
As reported in the abstract
Time to first awakening (phase I)
P = 0.6
Further findings
Time to ICU discharge (phase II) · no statistical difference · primary endpoint, phase II
P = 0.3
| Outcome | C+SP | SP | P value |
|---|---|---|---|
| Duration of MV, phases I and II together (post-hoc)No cycloergometry vs Cycloergometry · significantly longer without cycloergometry · post-hoc analysis | P = 0.04 | ||
| Time from hemodynamic stability to ICU discharge (post-hoc)C+SP in phase I and/or II vs SP only · trend · post-hoc analysis | — not stated in the abstract | 20 (IQR 11–66) days | P = 0.052 |
— not stated in the abstract
- Duration of mechanical ventilation (MV), phases I and II together (post-hoc): No cycloergometry median 14 (IQR 8–60) days
- Duration of MV, phases I and II together (post-hoc): Cycloergometry median 9 (IQR 6–17) days
- Time from hemodynamic stability to ICU discharge (post-hoc): C+SP in phase I and/or II 13 (IQR 8–33) days
Original publication
Early mobilization with or without cycloergometry in patients with septic shock in Intensive Care Unit: a randomized controlled trial. Ann Intensive Care. Published 20 February 2026. doi:10.
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