Respiratory failure & ventilation
Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial
Primary resultResult — go to the resultRelative risk 0.65 95% CI 0.48–0.90Authors' conclusion
In patients with mild acute respiratory failure treated in nonintensive care wards, early NIV reduced the progression to severe acute respiratory failure.
Study context
- Population
- Adults with mild acute respiratory failure (Pao2/FiO2 ratio ≥200) in nonintensive care wards, 11 hospitals in Italy, Greece and Kazakhstan1 withdrew consent
- Participants
- 524 adults
- Comparison
- Early noninvasive ventilation (NIV) vs usual care
- Early NIVn = 265
- Usual caren = 258reference
- Primary endpoint
- Progression to severe acute respiratory failure (severe hypoxaemia, severe respiratory distress, or hypercapnic acidaemia)
- Follow-up
- During hospitalisation
Methodological detailsopen-label, multinational, multicentre
- Open-label
- Multinational
- Multicentre
Primary result
As reported in the abstract
Relative risk
0.65
95% CI 0.48–0.90
P = 0.0080
Events by treatment group
Early NIV vs Usual care
RR 0.65 (95% CI 0.48–0.90); P = 0.0080
Further findings
Hospital LOS
P = 0.30
Respiratory complications and 28-day mortality
- Not different between early NIV and usual care
Safety
Adverse events
- Not different between early NIV and usual care
Original publication
Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial. Br J Anaesth. Published 2 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →