Perioperative medicine & outcomes
Early plasma syndecan-1 dynamics and their prognostic value in major thoracic and abdominal surgery: a prospective observational study
Authors' conclusion
Syndecan-1 levels vary widely postoperatively and are not associated with key perioperative variables or outcomes.
Study context
- Population
- Patients undergoing major thoracic and abdominal surgery
- Participants
- 107 patients
- Outcome
- Early postoperative changes in plasma syndecan-1 and their association with postoperative complications
- Follow-up
- 30 days
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Plasma syndecan-1 after surgery; prediction of major complications and mortality within 30 days · 2 h after surgery
| Group | Value | AUC for major complications and mortality within 30 days | AUC 95% CI | AUC p |
|---|---|---|---|---|
| Syndecan-1 | median 958 (IQR 654–2665) pg/mL | 0.52 | 0.40-0.63 | p = 0.765 |
Syndecan-1
Valuemedian 958 (IQR 654–2665) pg/mL
AUC for major complications and mortality within 30 days0.52
AUC 95% CI0.40-0.63
AUC pp = 0.765
- No significant associations with comorbidities, surgical approach, intraoperative factors, or complications
- all p > 0.05
Observational data: associations, not effects.
Further findings
| Outcome | Values | AUC (95% CI) | P value |
|---|---|---|---|
| Prediction of major complications and mortality within 30 days (ROC)Poor predictive performance | Syndecan-1 AUC 0.52 | 0.52 (0.40–0.63) | P = 0.765 |
Original publication
Early plasma syndecan-1 dynamics and their prognostic value in major thoracic and abdominal surgery: a prospective observational study. Perioper Med (Lond). Published 2 January 2026. doi:10.
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