Perioperative medicine & outcomes
Trajectory of plasma syndecan‐1 and heparan sulphate during major surgery: A retrospective observational study
Authors' conclusion
Changes in syndecan-1 and heparan sulphate after surgery appear to show three different patterns, with the greatest increases in those patients with greater blood loss, more liver surgery and longer operations.
Study context
- Population
- Patients undergoing major abdominal surgery (specimens from a trial)
- Participants
- 72 patients
- Outcome
- Perioperative trajectory of plasma syndecan-1 and heparan sulphate (measured on five occasions)
- Follow-up
- Baseline to second POD
Main finding
As reported in the abstract
Three different temporal patterns of plasma syndecan-1 concentration
3
Group 1 'low': minor syndecan-1 changes from baseline; median heparan sulphate increase (p < .005)
67%
Group 2 'increase': median plasma syndecan-1 from 27 to 118 μg/L during first POD (p < .001)
27 μg/L to 118 μg/L
Group 2 'increase': median plasma heparan sulphate from 279 to 2196 μg/L (p < .005)
+670%
Observational data: associations, not effects.
Further findings
Plasma C-reactive protein, colon surgery, dexamethasone, surgical factors
- Colon surgeries occurring in Group 1
- 90%
- Plasma C-reactive protein did not differ across the three groups
- Dexamethasone treatment similar across the three groups
- Surgical blood loss, duration of surgery and liver resection greatest in Group 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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