Perioperative medicine & outcomes
Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study
Authors' conclusion
As higher IL-6 and sIL-6R levels were significantly associated with higher risk of POD and the combination is required for IL-6 trans-signaling, it is possible that activation of this pathway may be associated with POD.
Study context
- Population
- Patients >60 years old scheduled for major lower limb surgery under GA126 analysed
- Participants
- 188 patients
- Exposure
- Fluctuating higher vs stable lower plasma IL-6 and sIL-6R trajectories
- Outcome
- POD (confusion assessment method, twice daily) and its association with plasma cytokines
- Follow-up
- 4 days
Methodological detailslongitudinal, group-based trajectory modeling, time-dependent Cox regression
- Longitudinal
- Group-based trajectory modeling
- Time-dependent Cox regression
Main finding
As reported in the abstract
POD and plasma cytokines (IL-6, sIL-6R)
Postoperative delirium (POD) diagnosed
31 of 126 patients
24.6%
Delirious, fluctuating higher vs stable lower IL-6 trajectory
73.3% vs 18.0%
P = .001
Delirious, fluctuating higher vs stable lower sIL-6R trajectory
81.3% vs 16.4%
P = .001
Observational data: associations, not effects.
Further findings
Delirium by IL-6 trajectory
P = 0.001
Delirium by sIL-6R trajectory
P = 0.001
Original publication
Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Anesth Analg. Published 26 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →