Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension
Primary resultResult — go to the resultEstimated difference −0.9 percentage points 95% CI −4.4 to 2.6Authors' conclusion
Among patients with sepsis-induced hypotension, the restrictive fluid strategy that was used in this trial did not result in significantly lower (or higher) mortality before discharge home by day 90 than the liberal fluid strategy.
Study context
- Population
- Patients with sepsis-induced hypotension refractory to initial 1 to 3 liters of intravenous fluid, randomised within 4 hours
- Participants
- 1,563 patients
- Comparison
- Restrictive vs liberal fluid strategy for 24 h
- Restrictive fluidn = 782
- Liberal fluidn = 781reference
- Primary endpoint
- All-cause mortality before discharge home
- Follow-up
- Day 90
Methodological detailsunblinded, superiority, multicentre (60 US centers)
- Unblinded
- Superiority
- Multicentre (60 US centers)
Primary result
As reported in the abstract
Estimated difference
−0.9 percentage points
95% CI −4.4 to 2.6
P = 0.61
Events by treatment group
Restrictive fluid vs Liberal fluid
estimated difference −0.9 percentage points (95% CI −4.4 to 2.6); P = 0.61
Further findings
| Outcome | Difference of medians (ml) (95% CI) | |
|---|---|---|
| Intravenous fluid volume during 24-h protocol period | −2134 (−2318 to −1949) | |
| −3000−2000−100001000Difference, ml (linear scale) |
Intravenous fluid volume during 24-h protocol period
- Restrictive fluid group had earlier, more prevalent, and longer duration of vasopressor use
Safety
- Number of reported serious adverse events similar in the two groups
Original publication
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. Published 21 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →