Vasopressors or Fluids in Early Septic Shock
Primary resultResult — go to the resultDifference 0.0 days 95% CI −2.7 to 2.7Authors' conclusion
Among adult patients who presented to the emergency department with septic shock, an approach that involved restricted fluid volume and early vasopressors did not result in a greater number of days alive and out of the hospital at day 90 than an approach involving greater fluid volume and later administration of vasopressors.
Study context
- Population
- Adults presenting to the ED with septic shock963 in ITT population
- Participants
- 1,000 adults
- Comparison
- Vasopressor vs Fluids
- Vasopressorn = 499
- Fluidsn = 501reference
- Primary endpoint
- Days alive and out of hospital from randomisation to day 90
- Follow-up
- Day 90
Primary result
As reported in the abstract
Difference
0.0 days
95% CI −2.7 to 2.7
P = 1.00
By group
Vasopressor vs Fluids
difference 0.0 days (95% CI −2.7 to 2.7); P = 1.00
Further findings
| Outcome | Median difference (ml) (95% CI) | |
|---|---|---|
| IV fluid received · first 24 hours | −1108 (−1395 to −850) | |
| −2000−100001000Difference, ml (linear scale) |
| Outcome | Difference (percentage points) (95% CI) | |
|---|---|---|
| Patients receiving vasopressors | 18.9 (13.3–24.5) | |
| −100102030Difference, percentage points (linear scale) |
Safety
Pulmonary edema
P < 0.001
Other adverse events
- Similar percentages in the two groups
Original publication
Vasopressors or Fluids in Early Septic Shock. N Engl J Med. Published 11 June 2026. doi:10.
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