Neuroanesthesia & neurocritical care
Early seizures and heterogeneity of physiologic recovery in heat-related illness: a nationwide registry study
Authors' conclusion
Early seizures in heat-related illness were associated with a distinct short-interval trajectory phenotype that may help calibrate early prognostication.
Study context
- Population
- Adults hospitalized with heat-related illness, JAAM-HsS registry, 2017–2024
- Participants
- 3,859 adults
- Exposure
- Early seizures vs no early seizures
- Early seizuresn = 408
- Without early seizuresn = 3,451reference
- Outcome
- Day 1-Day 2 short-interval trajectories of key metabolic, electrolyte and fluid-balance markers by early seizure status (seizure-by-time interactions)
- Follow-up
- Day 1-Day 2
Methodological detailsnationwide registry, linear mixed-effects models, 1:1 propensity score matching
- Nationwide registry
- Linear mixed-effects models
- 1:1 propensity score matching
Main finding
As reported in the abstract
- More rapid normalization of base excess, lactate, glucose and serum sodium by Day 2 with early seizures
- all interaction p < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | Early seizures | Without early seizures | aOR (95% CI) | |
|---|---|---|---|---|
| In-hospital mortalityLactate-included model · secondary observational outcome | 6.6% | 5.2% | 0.48 (0.27–0.86) | |
| In-hospital mortalityLactate-excluded model · secondary observational outcome | 0.57 (0.33–0.99) | |||
| 0.20.5125Adjusted odds ratio (log scale) |
In-hospital mortality
- Inverse association directionally consistent after propensity score matching
Original publication
Early seizures and heterogeneity of physiologic recovery in heat-related illness: a nationwide registry study. Crit Care. Published 20 March 2026. doi:10.
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