Neuroanesthesia & neurocritical care
Noradrenaline‐induced changes in cerebral blood flow in health, traumatic brain injury and critical illness: a systematic review with meta‐analysis
Authors' conclusion
Noradrenaline significantly increases cerebral blood flow in humans with impaired, not intact, cerebral autoregulation, with the extent of changes related to the severity of functional impairment, the extent of mean arterial pressure changes and pre-treatment blood pressure levels.
Study context
- Population
- Healthy participants and patients with TBI and critical illness28 studies
- Comparison
- Noradrenaline-induced changes in cerebral blood flow across healthy, TBI and critically ill populations
- Outcome
- Change in cerebral blood flow (velocity) with noradrenaline
Pooled result
As reported in the abstract
Change in cerebral blood flow velocity
Change, % (95% CI)
Healthy/no critical illness or TBI
−1.7(−4.7-1.3)
TBIsignificant increase
21.5(11.0–32.0)
Critically illsignificant increase
20.0(9.7–30.3)
Further pooled results
Change in MAP
| Increase (%) (95% CI) | ||
|---|---|---|
| Healthy/no critical illness or TBI | 24.1 (19.4–28.7) | |
| TBI | 33.8 (14.7–52.9) | |
| Critically ill | 32.4 (25.0–39.9) | |
| −50050100Difference, % (linear scale) |
Cerebral autoregulation
- Analyses suggest intact autoregulation in healthy/no critical illness or TBI, impaired in TBI and critically ill
Non-transcranial Doppler methods
- Studies inadequate and heterogeneous for meaningful meta-analysis
Original publication
Noradrenaline‐induced changes in cerebral blood flow in health, traumatic brain injury and critical illness: a systematic review with meta‐analysis. Anaesthesia. Published 3 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →