Early Sepsis-Associated Acute Kidney Injury and Obesity
Authors' conclusion
In this cohort study of patients with sepsis, obesity was associated with a higher risk of early SA-AKI and the presence of SA-AKI modified the association of obesity with clinical outcomes.
Study context
- Population
- Adults aged ≥19 years with sepsis admitted to 20 tertiary hospital intensive care unit (ICUs) in Korea, Sept 2019–Dec 2021; excluding preexisting stage 3A–5 CKD and missing body mass index (BMI)
- Participants
- 4,041 adults
- Exposure
- Obesity vs normal weight
- Outcome
- Early SA-AKI incidence
- Follow-up
- Within 48 hours of ICU admission
Methodological detailsnationwide, multicentre (20 tertiary hospital ICUs)
- Nationwide
- Multicentre (20 tertiary hospital ICUs)
Main finding
As reported in the abstract
Early SA-AKI
Estimate (95% CI)
Obesity vs Normal weight
aOR 1.40(1.15–1.70)
Every increase in BMI of 10
OR 1.75(1.47–2.08)
- Developed early sepsis-associated acute kidney injury (SA-AKI) (all patients)
- 1367 (33.8%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| In-hospital mortality, patients without SA-AKI (subgroup)Obesity vs No obesity (underweight, normal weight, overweight) | 0.72 (0.54–0.94) | |
| In-hospital mortality, patients with SA-AKI (subgroup)Obesity vs No obesity (underweight, normal weight, overweight) | 0.85 (0.65–1.12) | |
| 0.512Adjusted odds ratio (log scale) |
Clinical recovery (survival to discharge within 30 days)
- Greater likelihood with obesity without SA-AKI vs no obesity; less likely with both obesity and SA-AKI
Original publication
Early Sepsis-Associated Acute Kidney Injury and Obesity. JAMA Netw Open. Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →