ICU sedation, delirium & recovery
Early sitting within 72 hours in the intensive care unit and post–intensive care outcomes: a multicenter cohort study
Main finding · Death or functional decline, assessed using the Kihon ChecklistResult — go to the resultAdjusted relative risk 0.94 95% CI 0.80–1.09Authors' conclusion
Achieving sitting within 72 h of ICU admission was not associated with death or functional decline at 3 months. The exploratory associations with cognitive-functional impairment and readmission-related outcomes may reflect the selection of clinically stable patients for early sitting rather than an effect of sitting itself. These findings support the feasibility of early sitting in clinically stable patients but do not establish early sitting as a therapeutic target; randomized trials are needed.
Study context
- Population
- Mechanically ventilated adult intensive care unit (ICU) survivors who underwent rehabilitation
- Participants
- 423 patients
- Exposure
- Achievement of sitting within 72 h of ICU admission
- Outcome
- Death or functional decline, assessed using the Kihon Checklist
- Follow-up
- 3 months after hospital discharge
Methodological detailsoverlap propensity score weighting, prespecified sensitivity analyses, Benjamini-Hochberg (BH) multiplicity adjustment
- Overlap propensity score weighting
- Prespecified sensitivity analyses
- Benjamini-Hochberg (BH) multiplicity adjustment
Main finding
As reported in the abstract
Adjusted relative risk
0.94
95% CI 0.80–1.09
P = 0.401
Observational data: associations, not effects.
Further findings
| Outcome | aRR (95% CI) | P value | |
|---|---|---|---|
| Cognitive domain impairment or death (exploratory)Early sitting vs Did not achieve early sitting · BH-adjusted p = 0.096 · exploratory analysis | 0.80 (0.67–0.97) | P = 0.024 | |
| Readmission or death (exploratory)Early sitting vs Did not achieve early sitting · BH-adjusted p = 0.027 · exploratory analysis | 0.53 (0.32–0.88) | P = 0.014 | |
| 0.20.5125Adjusted relative risk (log scale) |
- Cognitive domain impairment or death (exploratory): the cognitive association was not observed under a stricter definition
- Readmission or death (exploratory): Associations with readmission-related outcomes were attenuated after adjustment for Day-3 clinical status
Individual KCL items
- No individual KCL item showed a clear association after weighting
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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