Respiratory failure & ventilation
Early time-course of respiratory mechanics, mechanical power and gas exchange in ARDS patients
Authors' conclusion
The alteration in oxygenation, dead space, and mechanical power ratio should be assessed not at intensive care admission, but during the first days of mechanical ventilation to better predict outcome.
Study context
- Population
- Mechanically ventilated ARDS patients, studied at intensive care unit (ICU) admission and the following 3 days
- Exposure
- Survivors vs non-survivors during ICU stay
- Outcome
- ICU mortality and associated variables (PaO2/FiO2 ratio, driving pressure, alveolar dead space fraction, mechanical power, mechanical power ratio)
- Follow-up
- ICU admission and first 3 days of mechanical ventilation
Main finding
As reported in the abstract
- Mechanical power ratio higher in non survivors at ICU admission and over time
- PaO2/FiO2 ratio higher in survivors, with similar behaviour over time in the 2 groups
- Alveolar dead space fraction similar between groups at ICU admission and over time
- Mechanical power ratio the only physiological variable consistently associated with ICU mortality throughout the study
- Univariate logistic regression
Observational data: associations, not effects.
Original publication
Early time-course of respiratory mechanics, mechanical power and gas exchange in ARDS patients. J Crit Care. Published 18 October 2023. doi:10.
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