Effect and safety profile of topical lidocaine on post-surgical neuropathic pain and quality of life: A systematic review and meta-analysis
Pooled result · Global pain reliefResult — go to the resultRelative risk 1.98 95% CI 1.04–3.76Authors' conclusion
Topical lidocaine may lead to pain relief and is safe to use for patient with post-surgical pain, though its impact on quality of life is unclear.
Study context
- Population
- Patients with post-surgical neuropathic pain
- Participants
- 585 patients · 7 randomized controlled trials (RCTs)
- Comparison
- Topical lidocaine vs placebo or no topical lidocaine
- Outcome
- Global pain relief
Methodological detailscertainty of evidence assessment
- Certainty of evidence assessment
Pooled result
As reported in the abstract
Relative risk
1.98
95% CI 1.04–3.76
P = 0.04
Topical lidocaine vs Placebo or no topical lidocaine
RR 1.98 (95% CI 1.04–3.76); P = 0.04
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Pain intensity reductionI2 = 93% · low certainty evidence | −0.70 (−1.46 to 0.06) | P = 0.07 | |
| −2−101Difference (linear scale) |
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Adverse eventsI2 = 0% · high certainty evidence | 1.04 (0.93–1.16) | P = 0.51 | |
| 0.512Relative risk (log scale) |
Original publication
Effect and safety profile of topical lidocaine on post-surgical neuropathic pain and quality of life: A systematic review and meta-analysis. J Clin Anesth. Published 10 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →