Multicenter, Randomized, Placebo-controlled Crossover Trial Evaluating Topical Lidocaine for Mechanical Cervical Pain
Authors' conclusion
The differences favoring lidocaine were small and nonsignificant
Study context
- Population
- Patients with mechanical neck pain at 4 US military, Veterans Administration, academic and private practice sitesrandomised
- Participants
- 76 patients
- Comparison
- Lidocaine patch vs placebo patch
- Primary endpoint
- Mean reduction in average neck pain; positive categorical outcome = reduction ≥2 points in average neck pain plus ≥5 of 7 on Patient Global Impression of Change
- Follow-up
- 4 weeks
Methodological detailsdouble-blind, placebo-controlled, crossover, multicentre
- Double-blind
- Placebo-controlled
- Crossover
- Multicentre
Primary result
As reported in the abstract
Reduction in average neck pain score
Lidocaine
−1.0
median · IQR −2.0–0.0
Placebo
−0.5
median · IQR −2.0–0.0
P = 0.17
Secondary outcomes
Positive categorical outcome
P = 0.073
Secondary outcomes
- Carryover effect on pain pressure threshold for the lidocaine phase
- P = 0.015
- No significant differences between treatments
Safety
Minor reactions (most commonly pruritis)
P = 0.36
Original publication
Multicenter, Randomized, Placebo-controlled Crossover Trial Evaluating Topical Lidocaine for Mechanical Cervical Pain. Anesthesiology. Published 11 December 2023. doi:10.
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